Objective The clinical data of different types of patients with COVID-19 were retrospectively analyzed to explore the clinical features of COVID-19.

Methods 119 cases of non-critical patients and 30 cases of critical patients with COVID-19 were recruited in Wuhan Huoshenshan Hospital from February 10-11, 2020. And the basic demographic characteristics, basic diseases, clinical manifestations and important test indicators of them were collected. Then the data of non-critical patients and critical patients were processed by statistical analysis.

Results There was no gender difference between the two groups, most of the critically ill patients were the elderly, and the clinical manifestations were most of the symptoms appeared together or successively. COVID-19 is often accompanied by underlying diseases, of which hypertension is the most common, followed by coronary heart disease and type 2 diabetes. 51.3%-63.3% of patients often suffer from hypertension, coronary heart disease, type 2 diabetes and other diseases at the same time. In addition, the lymphocyte count and lymphocyte percentage in critical COVID-19 patients were significantly lower than those non-critical patients, while white blood cell count, leukocyte percentage, C-reactive protein(CRP) and procalcitonin(PCT), creatine kinase(CK), creatine kinase isoenzyme(CK-MB), lactate dehydrogenase(LDH) and α-hydroxybutyrate dehydrogenase(α-HBDH) in critical patients were significantly higher than those in non-critical patients. In addition, there was a significant difference in stratified distribution between LDH and α-HBDH (P < 0.001), and the area under the curve of α-HBDH was as high as 0.936, which was higher than that of 0.775 of CK-MB.

Conclusions Compared with non-critical COVID-19 patients, critical COVID-19 patients are older, with more clinical manifestations and underlying diseases, more severe, more obvious inflammatory response. α-HBDH is an important index to judge critical degree and myocardial injury in patients with COVID-19.