Abstract: The outbreak and epidemic of the novel coronavirus pneumonia (COVID-19) has put forward higher requirements for the safety and security of blood collection and supply in medical institutions. Therefore, the Changhai Blood Station formulates the protection plan for voluntary blood donation during the period of epidemic prevention and control. According to the current characteristics of the novel coronavirus (SARS-CoV-2):long latency; the infection symptoms are diverse and hidden; mainly through droplets and contact transmission, etc. Take necessary protective measures for blood donors and staff, and reasonable disinfection of blood donation sites, to reduce the risk of cross-infection; through the return call of blood donors and a 14-day quarantine for the blood, the risk of the virus being transmitted through blood transfusions is minimized.