普通型新型冠状病毒肺炎患者咽拭子病毒核酸检测结果复阳情况分析

梁超; 费敏; 凌晓敏; 葛峰; 罗建飞; 仓静; 缪长虹

doi:10.12025/j.issn.1008-6358.2020.20200574

普通型新型冠状病毒肺炎患者咽拭子病毒核酸检测结果复阳情况分析

The analysis of re-positive rate of throat swab nucleic acid test in ordinary patients with COVID-19

摘要

摘要:
目的探讨普通型新型冠状病毒肺炎（COVID-19）患者住院期间咽拭子新型冠状病毒（SARS-CoV-2）核酸检测转阴后复阳的发生率及可能因素。
方法多次采集2020年2月2日至2020年3月10日武汉大学人民医院东院收治的40例确诊的普通型COVID-19患者咽拭子，采用实时反转录聚合酶链反应（RT-PCR）法进行SARS-CoV-2核酸检测。
结果所有患者在首次RT-PCR检测结果呈阴性后，第2次RT-PCR检测结果为阳性12例（30%），连续2次RT-PCR检测为阴性第3次检测为阳性的患者为13例（32.5%），连续3次RT-PCR检测阴性第4次检测为阳性的患者为3例（7.5%），连续4次RT-PCR检测为阴性第5次检测为阳性的患者为0例。
结论作为COVID-19患者确诊及出院的重要指标，咽拭子核酸检测存在一定的假阴性率。

Abstract:
Objective To explore the incidence and possible factors of regaining positive after pharynx swab novel coronavirus (SARS-CoV-2) nucleic acid test in patients with common novel coronavirus pneumonia (COVID-19) during hospitalization.
Methods Throat swabs of 40 patients with common COVID-19 were collected from February 2, 2020 to March 10, 2020 in the East Hospital of Renmin Hospital of Wuhan University, and SARS-CoV-2 nucleic acid was detected by real-time reverse transcriptase polymerase chain reaction (RT-PCR).
Results After the first RT-PCR test was negative in all patients, 12 cases (30%) were positive in the second RT-PCR test, 13 cases (32.5%) were positive in the third time after two consecutive RT-PCR tests were negative, and 3 cases (7.5%) were positive in the fourth time in 3 consecutive RT-PCR test negative patients. Among the patients who were negative for 4 consecutive RT-PCR tests, 0 patients were positive for the fifth time.
Conclusions As an important indicator of diagnosis and discharge of COVID-19 patients, pharyngeal swab nucleic acid test has a certain false negative rate.

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