Abstract: Coronavirus (coronavirus, CoVs) infection mainly affects the lungs. However, the effect of CoVs on cardiovascular system damage can not be ignored. Previous studies have shown that heart injury caused by CoVs infection is not rare, and its occurrence is closely related to the severity of the disease. Starting with the evidence of cardiovascular injury caused by CoVs, this paper further discusses the direct myocardial injury caused by CoVs, and the possible mechanism of RAS system activation, cytokine storm and inflammation on cardiovascular injury, and the possible mechanisms of cardiovascular injury, including:(1) direct action of virus:CoVs replicates in cardiomyocytes and injures myocardium; (2) activation of RAS system:after infection with CoVs, the expression of ACE2 is down-regulated and RAS system is activated, which enhances the vasoconstrictive function of Ang Ⅱ and weakens the protective effect of Ang1-7; (3) inducing cytokine storm:cardiac injury caused by circulating cytokines and systemic inflammatory response; (4) others:including hypoxemia and catecholamine cardiotoxicity. The purpose of this paper is to provide ideas for the follow-up detailed mechanism and treatment strategy research.