单中心肝细胞核因子1A失活型肝细胞腺瘤临床病理特征

韩晶; 陈伶俐; 张欣; 纪元

doi:10.12025/j.issn.1008-6358.2020.20200259

单中心肝细胞核因子1A失活型肝细胞腺瘤临床病理特征

Clinicopathological features of single-center hepatocyte nuclear 1A inactivated hepatocellular adenoma

摘要

摘要:
目的探讨肝细胞核因子1A（hepatocyte nuclear 1A，HNF1A）失活型肝细胞腺瘤（hepatocellular adenoma，HCA）的临床病理特征，提高此类肿瘤的认识。
方法收集2002年至2017年复旦大学附属中山医院经手术切除并诊断为HCA的102例病例资料，经免疫组化分型后，分析HNF1A失活型HCA的相关临床资料及观察形态学特点。
结果 HNF1A失活型HCA共17例，占16.7%（17/102）。女性患者与男性患者比例为13：4，平均年龄为33岁，均无糖尿病、糖原累积症及饮酒史。94.1%（16/17）病例因体检发现肝占位就诊。肿瘤多为单发（12/17），且形态学多为脂肪变性（12/17）。
结论 HNF1A失活型HCA较少恶变为肝细胞肝癌，在肝腺瘤病病例中，要警惕肿瘤异质性并密切随访。

Abstract:
Objective To analyze and summarize the clinicopathological features of hepatocyte nuclear 1A (HNF1A) inactivated hepatocellular adenoma (HCA) in order to improve the understanding of this kind of tumor.
Methods 102 cases of HCA diagnosed by surgical resection in Zhongshan Hospital, Fudan University from 2002 to 2017 were collected. After immunohistochemical classification, the relevant clinical data and morphological characteristics of HNF1A inactivated HCA were retrospectively analyzed.
Results 17 cases were HNF1A inactivated HCA. The ratio of female patients to male patients was 13:4, with an average age of 33 years old. All patients had no history of diabetes, glycogen storage diseases and alcohol consumption. 94.1% (16/17) cases were found by hepatic space occupying in physical examination. Most of the tumors were the single nodule(12/17). The majority future of morphology was steatosis(12/17).
Conclusion HNF1A inactivated HCA rarely turns into hepatocellular carcinoma (HCC). In hepatocelluar adenomatosis cases, we should pay attention to tumor heterogeneity and closely follow up.

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