Abstract: Since December 2019, novel coronavirus pneumonia has appeared in Wuhan, Hubei, China. Currently, there have been confirmed cases in many countries around the world. The disease spreads rapidly, and various evidences have shown that interpersonal transmission of NCP is occurring. However, for perioperative period, especially thoracic surgery, NCP patients have not been reported. This case mainly describes the whole process of diagnosis and treatment of a patient with lung cancer combined with NCP from preoperative examination to final diagnosis after operation, including the description of the patient's preoperative symptoms and signs, laboratory examination, and postoperative fever symptoms. The dynamic process of chest CT images and proper treatment and protective measures, as well as the diagnosis and treatment process after diagnosis provide experience for the diagnosis, treatment, and special protection for patients with perioperative thoracic surgery combined with NCP.