Objective To investigate the effect of transvaginal ultrasound-guided embryo transfer on the pregnancy outcomes of patients with repeated implantation failure (RIF).

Methods From June 2017 to June 2019, the clinical data of 48 in vitro fertilization and embryo transfer (IVF-ET) patients who underwent frozen-thawed embryo transfer again were analyzed retrospectively. According to whether the embryo transfer was guided by transvaginal ultrasound, they were divided into the experimental group (24 cases) and the control group (24 cases). The clinical embryo implantation rate, pregnancy rate, and spontaneous abortion rate between the two groups were analyzed and compared.

Results The clinical pregnancy rate (37.50%) in the experimental group and embryo implantation rate (29.26%) of the experimental group were significantly higher than those in the control group (29.16% and 21.05%, respectively), the differences were statistically significant (P < 0.05); there was no statistically difference in the abortion rate between the control group (14.28%) and experimental group (11.11%).

Conclusions Transvaginal ultrasound-guided embryo transfer could improve the clinical pregnancy outcomes of RIF patients.