Abstract: Granulosa cells (GCs) and oocytes are closely related with each other in structure and function. GCs surround the oocytes to form follicular, regulating the occurrence, development, maturation, and atresia of follicles. The changes of GCs morphology and function are also the starting of each developmental stage of follicles. The apoptosis of GCs directly affects the fate of oocytes and further determines the female reproductive function. Apoptosis of GCs is regulated by various factors including hormones, cytokines, etc. and involves changes of multiple signaling pathways. This article summarizes the signaling pathways involved in GCs apoptosis during follicular development and the role of GCs apoptosis in the development of oocytes and reproductive function of female.