Abstract: Objective：To analyze the effect of individual continuous improvement on the efficiency of patients with acute myocardial infarction in chest pain center. Methods：The patients with acute ST-segment elevation myocardial infarction treated in a chest pain center from January to April in 2017 and 2019 were included. There were 73 cases from January to April in 2017 (before improvement) and 52 cases from January to April in 2019 (after improvement). The total ischemia time, door to balloon time, first medical contact-balloon dilation time, hospital stay, and hospitalization expenses were compared and analyzed before and after the improvement. Results：After individualized continuous improvement, the door to balloon time decreased from (85.37±15.34) min to (72.66±19.98) min (P<0.01), puncture to balloon time decreased from (24.31±8.61) min to (16.68±8.36) min (P<0.01), first medical contact-balloon time decreased from (102.88±41.23) min to (93.64±39.41) min (P=0.038), hospital stay decreased from (10.06±3.20) d to (8.87±2.50) d (P=0.024), first medical contact-balloon time compliance rate increased from 67.31% (35/52) to 78.08% (57/73, P=0.028), the proportion of poor prognosis was significantly reduced from 27.40% (20/73) to 11.54% (6/52, P=0.043). Conclusions：Individualized continuous improvement can improve the treatment efficiency of acute ST-segment elevation myocardial infarction obviously.