Abstract: Soft tissue sarcoma is a rare malignant tumor originated from soft tissue. National Comprehensive Cancer Network (NCCN) has continually updated clinical practice guideline in soft tissue sarcoma. This article reviews the retroperitoneal soft tissue sarcoma section in the guideline, mainly involving the application of multi-discipline team (MDT) in the retroperitoneal sarcoma (RPS) treatment process, grading and staging, biopsy principles, surgical principles, radiotherapy principles, and other contents.