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腹型肥胖对正常体质指数老年人发生肌少症及骨质疏松的影响

Effect of abdominal obesity on sarcopenia and osteoporosis in elderly people with normal body mass index

  • 摘要: 目的:观察腹型肥胖对正常体质指数(BMI)老年人发生肌少症及骨质疏松的影响。方法:选择2018年1月至10月于江阴市人民医院老年医学科(全科医学科)就诊的年龄>60岁、体质指数(BMI)正常的老年人223例。根据内脏脂肪面积(VFA),将其分为腹型肥胖组113例(VFA>100cm2)和非腹型肥胖组110例(VFA≤100cm2)。分别测定两组受试者的BMI、血压、空腹血糖、空腹胰岛素(FINS)、VFA值、步速、握力、骨骼肌质量指数(ASMI)以及骨密度(BMD)等,通过t检验、卡方检验比较组间差异。采用Pearson相关分析探讨正常BMI老年人的VFA与肌少症及骨质疏松之间的关系。结果:腹型肥胖组和非腹型肥胖组VFA、ASMI、腰椎BMD差异有统计学意义(P<0.05)。腹型肥胖组肌少症、骨质疏松及骨质疏松合并肌少症发生率均明显高于非腹型肥胖组(P<0.05)。重度(VFA≥120cm2)、中度(110cm2≤VFA<120cm2)与轻度(100cm2≤VFA<110cm2)腹型肥胖组间ASMI及BMD差异均有统计学意义(P<0.05)。Pearson相关分析发现,BMI正常的腹型肥胖老年人的VFA与腰椎BMD(r=-0.416)、ASMI(r=-0.436)均负相关(P<0.05)。结论:即使BMI正常,腹型肥胖也可增加老年人发生肌少症与骨质疏松的风险;VFA越高,老年人肌少症及骨质疏松越严重。加强老年人群内脏型肥胖筛查对预防肌少症与骨质疏松的发生具有重要意义。

     

    Abstract: Objective:To investigate the effect of abdominal obesity on sarcopenia and osteoporosis in elderly people with normal body mass index (BMI). Methods:From January 2018 to October 2018, 223 elderly patients (age>60 years) with normal BMI were selected in the Department of Gerontology (General Medicine) in Jiangyin People’s Hospital. According to the visceral fat area (VFA), the patients were divided into abdominal obesity group (VFA>100 cm2, n=113) and non-abdominal obesity group (VFA≤100 cm2, n=110). The general situations and laboratory features such as BMI, blood pressure, fasting blood glucose, fasting insulin (FINS), VFA value, walking speed, grip strength, appendicular skeletal muscle mass index (ASMI), and bone mineral density (BMD) were measured, the differences between the two groups were compared by t test and chi-square test. The correlation between the VFA and sarcopenia and osteoporosis were analyzed using Pearson analysis. Results:The differences in VFA, ASMI, and lumbar BMD between the abdominal group and the non-abdominal group were statistically significant (P<0.05). The incidence of sarcopenia, osteoporosis, and sarcopenia combined with osteoporosis were higher in the abdominal group than those in the non-abdominal group (P<0.05). The differences of ASMI and BMD in the severe group (VFA≥120 cm2), moderate group (110 cm2≤VFA<120 cm2), and the mild group (100 cm2≤VFA<110 cm2) were statistically significant in the elderly with abdominal obesity (P<0.05). Pearson correlation analysis showed that VFA was negatively correlated with lumber BMD (r=-0.416) and ASMI (r=-0.436) in the elderly with abdominal obesity and normal BMI (P<0.05). Conclusions:Even with a normal BMI, abdominal obesity would increase the risk of sarcopenia and osteoporosis in the elderly. The higher VFA, the more severe the sarcopenia and osteoporosis will be in the elderly. Strengthening visceral obesity screening in the elderly is of great significance to prevent the occurrence of sarcopenia and osteoporosis.

     

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