Abstract: Objective：To analyze the effects of dexmedetomidine on hemodynamics, stress response, and incidence rate of secondary cerebral vasospasm (CVS) in anesthesia for interventional surgery of aneurysmal subarachnoid hemorrhage (aSAH). Methods：A total of 120 patients with aSAH undergoing interventional therapy in the hospital from April 2017 to June 2018 were divided into group D (use, n=60) and group C (no use, n=60) according to whether using the dexmedetomidine. The surgical conditions, hemodynamics, stress response, incidence rate of CVS, and prognosis were compared between the two groups. Results：The levels of mean arterial pressure (MAP) and heart rate (HR) in the two groups after anesthesia induction (T1) to the end of surgery (T4) were decreased compared with those before anesthesia induction (T0), and the two parameters showed increasing trends during extubation (T5), but the MAP level from T1 to T5 after tracheal intubation (T3) and the HR level at T1 to T5 time points in group D were significantly higher than those in group C (P<0.05). The neutrophil count (PMN) and malondialdehyde (MDA) in the two groups were increased, while superoxide dismutase (SOD) was decreased significantly at the end of surgery, 6 h and 24 h after surgery than before anesthesia induction. But the PMN and MDA in group D were lower than those in group C at each time point while the activities of SOD were higher than that in group C (P<0.05). The incidence rates of angiographically-confirmed vasospasm and symptomatic cerebral vasospasm in group D were significantly lower than those in group C (P<0.05). There was no significant difference in the hospital stay between the two groups. The proportion of GOS score of 1 to 3 points in group D was significantly lower than that in group C(P<0.05). Conclusions：Dexmedetomidine in interventional operation of aSAH can improve hemodynamics and reduce stress response and the incidence rate of CVS.