Abstract: Objective：To explore the application of xenogenic acellular dermal matrix and titanium-coated polypropylene mesh in immediate breast reconstruction after breast cancer resection and to compare their clinical effects and postoperative complications. Methods：From Jan. 2017 to Sep. 2018, 40 patients diagnosed with breast cancer undergoing breast resection and requiring immediate patch-based breast reconstruction were enrolled. Patients were divided into two groups: patients in group A were reconstructed with xenogenic acellular dermal matrix (n=21), patients in group B were reconstructed with titanium-coated polypropylene mesh (n=19). All patients underwent unilateral surgery. There was no significant differences in the general data between the two groups. Total drainage volume, duration of drainage, and complications were recorded after operation. Patients were followed up for 3 to 24 months, with an average of 11 months. Results：The mean total drainage volume of patients in group A was (658.29±72.82) mL, and its in group B was (576.58±92.06) mL, with significant difference between the two groups (P＜0.05). The mean time of duration of drainage in group A was (12.57±2.01) d, while that in group B was (10.21±1.87) d. The difference was statistically significant (P＜0.05). There was no case of skin flap necrosis, nipple areola necrosis, prosthesis exposure, patch exposure, or capsular contracture in both groups. Conclusions：Xenogenic acellular dermal matrix and titanium-coated polypropylene mesh implantation are easy to operate for immediate breast reconstruction. The two materials can be used for a less invasive and faster healing treatment.