Abstract: Objective：To investigate the feasibility and safety of preperitoneal repair of tissue defect with biological mesh after tumor resection in the iliac fossa and groin regions. Methods：The clinical data of 11 patients who were diagnosed as ilioinguinal tumor in Shanghai Public Health Clinical Center from January 2016 to October 2018 were retrospective analyzed. Results：Wounds in all cases healed in the stageⅠ, with a postoperative hospital stay time of 7-21 days (median of 13 days). During the follow-up time of 1-35 months after surgery, there was no incisional hernia or abdominal wall bulge. Ten patients had mild pain of the mesh fixed position, while the symptom disappeared in 2-4 weeks after operation. One patient had tumor recurrence. Conclusions：Preperitoneal repair of tissue defect with biological mesh may be safe and feasible after ilioinguinal tumor resection, and the short-term clinical efficacy is satisfactory, while the long-term results need further follow-up.