Abstract: Objective：To investigate the expression and correlation of insulin-like growth factor-Ⅱ (IGF-Ⅱ), insulin-like growth factor binding protein-1 (IGFBP-1), and resistin in patients with hypertensive disorder complicating pregnancy (HDCP). Methods：The 120 cases of HDCP were selected as case group, including 48 cases of gestational hypertension, 40 cases of mild preeclampsia, and 32 cases of severe preeclampsia. Meanwhile, 50 cases of normal pregnancy placenta were selected as control group. The expressions of IGF-Ⅱ, IGFBP-1, and resistin were analyzed by using the immunohistochemical S-P method, and the correlation analysis was conducted to observe the prognosis of patients with HDCP. According to the prognosis, the patients were divided into poor prognosis group and good prognosis group, and the expressions of IGF-Ⅱ, IGF-BP-1 and resistin in placenta tissues were observed in the two groups. Results：Compared with control group, the positive expression rate of IGF-Ⅱ in the case group was significantly reduced, while the levels of IGFBP-1 and resistin were significantly increased (P<0.01). Within the case group, the positive expression rate of IGF-Ⅱ decreased gradually as the severity of the disease increased. The positive expression rates of IGFBP-1 and resistin increased gradually as the severity of the disease increased. The positive expression of IGFBP-1 and resistin in severe preeclampsia subgroup was significantly higher than that in the gestational hypertension subgroup; the positive expression level of IGF-Ⅱ in severe preeclampsia subgroup was significantly lower than that in the mild preeclampsia subgroup (P<0.05). According to Spearman correlation analysis, resistin was positively correlated with IGFBP-1 expression (r=0.5937, P<0.05), while negatively correlated with IGF-Ⅱ expression (r=-0.6785, P<0.05), and IGFBP-1 was negatively correlated with IGF-Ⅱ expression (r=-0.6774, P<0.05 ). Compared with the good prognosis group, positive expression of IGF-Ⅱ in the poor prognosis group was significantly lower, while the positive expression rates of IGFBP-1 and resistin were significantly higher, and the difference was statistically significant (P<0.05). Conclusions：IGF-Ⅱ, IGF-BP-1, and resistin may be involved in the occurrence and development of HDCP, and there is an interaction among them, which may have certain correlation with the severity and prognosis of the disease.