Abstract: Objective：To improve the clinical diagnosis and treatment of adultonset asthma.Methods：The clinical data of adultonset and newly diagnosed asthma including demography, allergic status, family history, acute aggravating factors, asthma control test (ACT) score, lung function, and followup treatment were collected in the Respiratory Department of Zhongshan Hospital, Fudan University from August 2015 to August 2016.Results：A total of 135 adultonset and newly diagnosed asthma patients were enrolled, with an average age of 43±12 years old. Totally, 79 underwent allergen tests (36 had positive results). The most common allergen was house dust mites (n=25, 69.44%). All 135 patients received serum total IgE test with an average value of (204.32 ± 26.67) U/mL. All 135 patients received lung function test with an average FEV1%pred and FeNO value of (80.87± 20.9)% and (92.19±83.97) ppb (1 ppb=1 μL/m3), respectively. In the 135 cases, 8 cases were in intermittent state, 19 cases in mild persistent state, 17 cases in moderate persistent state, and 91 cases in severe persistent state. There was no correlation between FeNO and serum total IgE in 135 patients. But FeNO was positively correlated with serum total IgE in 77 allergic asthmatic patients (r=0.245，P＜0.05). There was no correlation between FeNO and FEV1% pred in 135 asthma patients and 77 allergic asthma patients. After three months of treatment, FEV1%pred was (91.87±16.5)% and FeNO was (57.59±23.98) ppb, and the difference before and after treatment is statistically significant (P＜0.05).Conclusions：Adultonset asthma is common, and there is often a history of smoking and allergies. The most asthma patients have late visits, but after regular treatment, symptoms and lung function can be significantly improved.