肝内胆管癌TRIM44、基质金属蛋白酶9蛋白的表达及临床意义

彭睿; 黄晓勇; 蔡加彬; 柯爱武; 施国明; 柏斗胜

doi:10.12025/j.issn.1008-6358.2018.20180698

肝内胆管癌TRIM44、基质金属蛋白酶9蛋白的表达及临床意义

Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma

摘要

摘要: 目的：探讨TRIM44和基质金属蛋白酶9(MMP9)蛋白在肝内胆管癌（ICC）中的表达及临床意义。方法：采用免疫组织化学法检测87例ICC患者肿瘤组织TRIM44、MMP9蛋白的表达，进一步分析两者表达与患者临床病理指标及预后的相关性；采用Spearman相关性分析探讨TRIM44和MMP9表达的相关性；采用Kaplan-Meier法和Cox风险回归模型分析TRIM44、MMP9表达对患者预后的影响。结果：ICC肿瘤组织TRIM44、MMP9蛋白呈过表达状态，且TRIM44与MMP9表达正相关(P<0.001)。TRIM44与淋巴结转移显著相关(P=0.014)；MMP9与肿瘤大小、AFP水平与淋巴结转移显著正相关（P<0.05），两者同时过表达提示患者预后不良。结论：ICC组织TRIM44和MMP9呈过表达，且二者密切相关；两者同时高表达提示ICC患者预后不良。

Abstract: Objective：To investigate the expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma (ICC). Methods：The expression of TRIM44 and MMP9 in 87 ICC patients were analyzed by immunohistochemistry. And the clinical significance of TRIM44 and MMP9 were investigated by Kaplan-Meier and Cox regression models. Results：The expressions of TRIM44 and MMP9 were upregulated in tumor tissues of ICC. TRIM44 was positively associated with MMP9 expression in ICC (P<0.001). TRIM44 expression was significantly correlated with the lymph node metastasis (P=0.014), and MMP9 was significantly correlated with the tumor size, AFP concentration, and lymph node metastasis (P<0.05). Simultaneous overexpression of TRIM44 and MMP9 suggested poor prognosis of ICC patients. Conclusions：TRIM44 and MMP9 are overexpressed in ICC and are closely related to each other. The high expressiones of both suggest poor prognosis of ICC patients.

HTML全文

参考文献(0)

施引文献

资源附件(0)