Abstract: Objective：To investigate the efficacy of Yishenjianpishugan recipe on the treatment of letrozole-induced bone loss in postmenopausal breast cancer patients. Methods：Fifty-seven postmenopausal breast cancer patients with diagnosed letrozole-induced bone loss were randomly divided into the control group (n=29) and the treatment group (n=28). The control group received the treatment of letrozole and calcium carbonate D3 tablets. The treatment group was treated with letrozole, calcium carbonate D3 tablets,and Yishenjianpishugan recipe. After one-year treatment, the bone mass, bone metabolism, clinical symptoms, and physical performance scores of patients were compared between the two groups, and the safety and efficacy of Yishenjianpishugan recipe were also assesed. Results：After one-year treatment with Yishenjianpishugan recipe, the bone mass, clinical symptoms, and physical status of the patients in the treatment group were significantly improved compared with those in the control group. However, there was no significant difference in bone metabolism of patients between the two groups; no obvious side effects were observed in patients with the treatment of Yishenjianpishugan recipe. Conclusions：Yishenjianpishugan recipe can effectively treat letrozole-induced bone loss in postmenopausal breast cancer patients, and effectively improve the patient’s clinical symptoms and physical conditions. Moreover, Yishenjianpishugan recipe has relatively mild toxicity and is worthy of clinical application.