摘要:
目的:探讨糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的相关危险因素及DPN患者血清中神经元特异性烯醇化酶(neuron-specific enolase,NSE) 水平的变化及临床意义。方法:根据是否合并周围神经病变,将736例2型糖尿病(type 2 diabetes mellitus,T2DM)患者分为DPN组(n=450)和单纯T2DM(SDM) 组(n=286)。分析两组病程、有无合并高血压、性别、年龄、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、NSE与DPN发生的相关性及NSE水平与其他指标的相关性。结果:住院T2DM患者DPN的患病率为61.1%。与SDM组相比,DPN组T2DM病程较长、高血压比例较高、年龄较大(P<0.05);两组NSE浓度差异无统计学意义。Logistic回归分析示,T2DM病程、年龄、HbA1c是DPN发生的独立影响因素(P<0.05)。多重线性回归分析示,DBP、BMI与NSE水平独立相关(P<0.05)。结论:T2DM病程长、高龄、HbA1c水平高可导致DPN的发生;NSE可能不是DPN潜在的生物学标志物。
Abstract:
Objective:To explore the the risk factors of diabetic peripheral neuropathy (DPN) and the changes and clinical significance of neuron-specific enolase (NSE) in serum of DPN patients. Methods:According to the combination of peripheral neuropathy or not, 736 patients with type 2 diabetes mellitus (T2DM) were divided into DPN group (n=450) and single T2DM (SDM) group (n=286). The correlation between duration of disease, presence or absence of combined hypertension, sex, age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), NSE and DPN, and the correlation between NSE and other indicators were analyzed. Results:The prevalence rate of DPN in hospitalized patients with T2DM was 61.1%. Compared with SDM group, DPN group had a longer course of T2DM, a higher proportion of hypertension, and an older age (P<0.05); there was no significant difference in NSE concentration between the two groups. Logistic regression analysis showed that the course, age, and HbA1c of T2DM were independent influencing factors for DPN (P<0.05). Multiple linear regression analysis showed that the diastolic blood pressure and BMI were independently correlated with NSE level (P<0.05). Conclusions:Long course of disease, old age, and high level of HbA1c of T2DM can lead to DPN. NSE may not be a potential biological marker for DPN.