Abstract: Objective：To evaluate the effect of oral pregabalin capsules before anesthesia induction on hemodynamic changes induced by tracheal intubation after induction of general anesthesia. Methods：A total of 53 patients were included in the study during September 2016 and December 2016 consecutively. The patients were randomly assigned into two groups: 26 patients in the control group and 27 patients in the pregabalin group (administrated 150 mg pregabalin orally 1 hour before surgery). The sedation grade (Ramsay score) was assessed before and one hour after medication. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded before medication, tracheal intubation, and 0, 1, 3, 5, 7, and 10 minutes after intubation. Perioperative adverse drug reactions were also recorded. Results：In the pregabalin group, the SBP and DBP at 1, 3, and 5 minutes after tracheal intubation were lower than those in the control group (P<0.05). The HR of 1 minute after intubation showed significant difference from the control group (P<0.05). The Ramsay score was significantly higher in the pregabalin group than that in the control group at 1 hour after medication (P<0.001). There was no statistical difference in the incidence of perioperative adverse reactions between the two groups. Conclusions：Preoperative oral administration of 150 mg pregabalin can effectively attenuate the hemodynamic response after intubation and reduce the preoperative anxiety with no significant side effects.