Abstract: Objective：To investigate the clinicopathologic features of invasive micropapillary carcinoma (IMPC) of breast. Methods：The clinical and pathologic features of 205 cases of breast IMPC during June 1993 to July 2017 were retrospectively analyzed. A total of 410 patients with invasive ductal carcinoma excluding IMPC in the same period were selected as control. Results：There were statistically significances in the age distribution, tumor size, lymph node metastasis rate, histological grading, progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression, value of Ki-67, molecular classification between IMPC and IDC patients (P<0.05). However, estrogen receptor (ER) status was not statistically significant. Conclusions：IMPC is a rare type of breast cancer with aggressive growth. Patients with IMPC were usually younger, with larger tumors, but higher lymph node metastasis rate, histological grade, hormone receptor positive and HER2 negative rates. There was a higher proportion of Luminal B breast cancer in IMPC, and lower in triple negative breast cancer.