Abstract: Objective：To evaluate the safety and efficacy of right ventricular active electrode on cardiac function in patients with bradycardiac arrhythmia. Methods：A total of 56 patients with bradycardiac arrhythmia who needed permanent pacemaker implantation were enrolled (42 patients were implanted with DDD pacemaker). Follow-up was carried out at the 1st, 3rd, 6th, and 12th months after operation, and once a year after 12 months. The patients’ clinical symptoms, quality of life, 6-min walk test (6MWT), serum level of brain natriuretic (BNP), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), and pacing parameters were evaluated at the 6th month after surgery. The changes of the above indexes before and 6 months after surgery were compared. Results：Six months after pacemaker implantation, the quality of life, 6MWT and BNP measurements of patients were significantly improved compared with those before surgery, the difference was statistically significant (P<0.05). But there was no statistical difference between LVEF and LVEDD. In some patients with mild cardiac insufficiency, the LVEF difference was statistically significant (P<0.05). Conclusions：Right ventricular septal pacing is safe and feasible. It can increase left ventricular ejection fraction without affecting biventricular synchrony and can replace right ventricular apex pacing.