Abstract: Objective：To compare the clearance effect on serum fibroblast growth factor-23 (FGF-23) between traditional hemodialysis (HD) and HD combined with hemoperfusion (HP).Methods：Totally 60 maintenance hemodialysis (MHD) patients from January 2016 to June 2016 in Central Hospital of Jiading District in Shanghai were randomly divided into HD group (30 cases) and HD+HP group (30 cases). The patients in HD group underwent HD (3 times/week, 4 h/time), the patients in HD+HP group underwent HD (2 times/week, 4 h/time), HD combined with HP (1 time/week, 2 h/time) then change into HD for 2 h. The treatment lasted for 6 months. The data of serum phosphorus (P), calcium (Ca), urea nitrogen (BUN), creatinine (Scr), intact parathyroid hormone (iPTH), FGF-23 levels were collected before and after study.Results：There were no significantly differences of BUN, Scr, Ca, P, iPTH, FGF-23 between HD group and HD+HP group at the beginning of study. After 6 months treatment, the levels of BUN and Scr were significantly decreased (all P＜0.05) in both groups. The levels of P, iPTH, and FGF-23 were significantly decreased after treatment in HD+HP group (all P＜0.05). The levels of P, iPTH, and FGF-23 in HD+HP group were significantly lower than those in HD group (P＜0.05) at the end of study, and no significantly differences of Hb, Alb, BUN, Scr were found between groups.Conclusions：Compared with HD, HD combined with HP treatment can significantly reduce the levels of P, iPTH, and FGF-23 in serum of MHD patients.