Abstract: Objective：To explore the application of evidence-based nursing in functional exercise of patients after total hip replacement. Methods：Totally 60 patients after total hip replacement from May 2015 to May 2016 were randomly divided into control group (n=30) undergoing functional exercise according to the routine nursing requirements of Orthopedics Department, and observation group undergoing functional exercise according to the evidence-based nursing (n=30). In observation group, the relevant nursing problems were submitted, then the start time of functional exercise, the time and methods of early functional exercise, the optimal method of functional exercise, the methods for reducing the pain during exercise and the ways to promote the compliancy of functional exercise were analyzed through literature retrieval of nursing evidences, so as to formulate an exercise scheme. The degree of pain, Harris hip score, incidence of dislocation and compliance rate of functional exercise were compared between two groups. Results：No significant difference in NRS score three days after operation was found between two groups, while the NRS score in observation group was significantly lower than that in control group 1 week and 2 weeks after operation (P＜0.05). Two weeks after operation, the Harris hip score in observation group was significantly higher than that in control group (P<0.05). No dislocation was observed in both groups and the compliance rate of functional exercise in observation group was significantly higher than that in control group (P<0.05). Conclusions：Evidence-based nursing can reduce the pain of patients during functional exercise after total hip replacement, which can promote the recovery of hip function and improve the compliance rate of functional exercise effectively.