Abstract: Subthalamic nucleus (STN) is the main target nucleus for deep brain stimulation (DBS) treatment in patients with Parkinson disease. To implant the electrode on the sensorimotor part of STN individually and accurately, the boundary of STN is required to be clarified clearly on the magnetic resonance imaging (MRI) without geometric distortion. At present, there are three categories of MRI sequences: spin echo sequence including T2-weighted imaging (T2WI), inversion recovery (IR), diffusion tensor imaging (DTI), and fractional anisotropy (FA); magnetization transfer technique including magnetic susceptibility weighted imaging (SWI) and T2-weighted magnitude imaging (T2*WI); image reconstruction technique such as quantitative susceptibility mapping (QSM). It is found that QSM can provide optimal signal-noise ratio to identify the boundary of STN, T2* technique comes second. T2WI has high geometric accuracy when the patients wear frame, which is appropriate for direct DBS implantation on STN with frame.