Abstract: Objective：To observe the efficacy of reducing cardiovascular events and safety in maintenance hemodialysis(MHD) patients combined with diabetes mellitus by taking aspirin. Methods：MHD patients with diabetes were randomly divided into treatment group and control group. The treatment group was treated with aspirin. Results：Totally 86 patients were selected, in which 42 cases in treatment group and 44 cases in control group. There was no significant difference in the incidence of all-cause mortality and incidence rate of cardiovascular and cerebrovascular between the two groups, and no significant difference was found in bleeding between the two groups. Conclusions：The effect of aspirin in reducing the incidence of cardiovascular and cerebrovascular events in MHD patients combined with diabetes mellitus is not clear，but also show no significant increase in bleeding.