Abstract: Objective：To explore the diagnostic value of low dose multi-detector computed tomography urography(CTU) in patients with urinary tract diseases.Methods：Sixty patients who were treated with CTU from January 2015 to December 2016 were included in this study. All patients were divided into three groups according to the random number method. Group Ⅰ(160 mA tube current), group Ⅱ (120 mA tube current) and group Ⅲ (80 mA tube current), the selected patients were taken to the corresponding tube current CTU. The diagnostic efficacy of three groups of uropathy was analyzed, and the three groups of CTU imaging results, iodine contrast agent dosage and radiation dose of the situation were compared. Results：The dose of iodine contrast agent and the effective dose of radiation in group Ⅲ were lower than those in group Ⅰ and group Ⅱ, and the dose of radiation and dose of iodine contrast agent in group Ⅱ were lower than those in group Ⅰ(P<0.05). The difference of CTU imaging scores between the three groups was not statistically significant. Conclusions：The diagnostic value of low-dose (80 mA tube current) CTU in the clinical diagnosis of urinary tract diseases is similar to the high-dose CTU, with the iodinated contrast agent dosage and effective dose of radiation reduced significantly, which is worth of clinical promotion.