Abstract: Vascular aging is one of the most common diseases, which affect human health and quality of life. It can occur in a variety of blood vessels, such as aorta, coronary artery, cerebral vessels and peripheral blood vessels. Atherosclerosis (AS) is the main pathological basis of vascular aging, and many risk factors can promote the development of AS. AS caused by the imbalance of glucose and lipid homeostasis is closely related to vascular aging, and plays an important role in the development of vascular diseases in the elderly. As a basis for the development of vascular disease, how AS participates in vascular aging and how AS and vascular aging influence each other are hot research topics in the academic field at present. This paper reviews the correlation between glucoselipid homeostasis imbalance AS and vascular aging, and research progress. It is hoped that it will contribute to the understanding of vascular aging so as to provide early intervention.