Abstract: Objective：To discuss the early predict value of sequential organ failure assessment（SOFA）score of 28days mortality in liver transplantation patients. Methods：Totally 64 patients who received liver transplantation in Department of Hepatic Surgery in Zhongshan Hospital affiliated to Fudan University were enrolled during January 2015 to September 2016. Patients general information, laboratory results on admission and postoperative days (POD) 1-7 (POD1-7) and, operation indexes and 28days mortality were analyzed. Results：The cutoff point of SOFA score of POD17 was 5.5, sensitivity and specificity of SOFA score predicting 28days mortality was 100% and 94.8%; 28days mortality of patients with SOFA score ＞5 was 33.3% (6/18); moreover, the levels of platelets, total bilirubin, prothrombin time, creatinine and Nterminal Btype natriuretic peptide（NT-proBNP）in patients with SOFA score ＞5 (n＝18) were of statistically significance compared to that of patients with SOFA score≤5 (n＝46), P＜0.05.Conclusions：SOFA score, which combined with the levels of platelets, bilirubin, prothrombin time, NTproBNP and creatinine can early and effectively predict 28days mortality in liver transplantation patients.