Abstract: Objective：To investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in the classification of renal cell carcinoma (RCC), and to evaluate the correlation between the perfusionrelated parameters (D* and f) and the percentage of enhanced lesion and microvascular density (MVD). Methods：The data of 57 pathologically confirmed cases of renal cell carcinoma (RCC) in 52 patients between May 2013 and March 2015 were retrospectively analyzed. All patients underwent conventional MRI and IVIM-DWI scanning. 36 cases of RCC in 34 patients underwent immunohistochemistry CD34 staining to evaluate MVD. Oneway ANOVA, Pearson correlation analysis and receiver operating characteristic (ROC) curve were used for statistical analysis. Results：The ADC and D values of clear cell renal cell carcinoma (ccRCC) were higher than those of papillary renal cell carcinoma (pRCC) and chromophobe renal cell carcinoma (chRCC, P＜0.01), but there was no significant statistical difference between the ADC and D values of pRCC and chRCC〖BP（〗 (P＝0.536). There was no significant statistical difference between the D* values of ccRCC and chRCC〖BP(〗 (P＞0.05)〖BP)〗. The f values of 3 subtypes of RCC were statistically different (all P＜0.05). The areas under the ROC curve (AUC) of ADC, D, D* and f values in the differentiation between ccRCC and nonccRCC were 0.84, 0.85, 0.65, and 0.80 respectively. The D* and f values were positively correlated with the percentage of enhanced lesions in corticomedullary phase and parenchymal phase (r=0.45, 0.30; 0.56, 0.55, respectively). The D* and f values were both positively correlated with the MVD value of renal cell carcinoma (r=0.362 and 0.501 respectively). Conclusions：IVIM-DWI is valuable in helping to differentiate among RCC subtypes. Perfusionrelated parameters D* and f have certain correlation with the percentage of lesion enhancement and MVD.