Abstract: Some kinds of bone infection are characterized by long course, treatment difficulty and poor prognosis, so early and accurate diagnosis is very important to them. The diagnosis of such infections are not always obvious by using traditional imaging procedures. 18F-FDG PET/CT is a functional imaging procedure that is widely used in the diagnosis of infection. In this paper, the role of 18F-FDG PET/CT in the diagnosis and curative effect evaluation of bone infection is reviewed.