Abstract: Objective：To examine the efficacy of analgesia using sequential patient controlled epidural analgesia (PCEA)parecoxib combined with modified Joel-Cohen incision for laparoscopic left lateral hepatectomy. Methods：From August 2013 to August 2016, 40 hepatocellular carcinoma (HCC) patients were enrolled and divided into PCEA group (n=20) and PCEA-parecoxib group (n=20). Patients in PCEA group received postoperative analgesia by using PCEA (bupivacaine 300 mg+fentanyl 500 μg+250 mL NS，4 mL/h pumping) , while those in PCEA-parecoxib group were subjected to PCEA and parecoxib (40 mg，iv，q12 h×2 d). The visual analog scale (VAS) was used to assess the degree of the postoperative pain. The times of bowel flatus, mobilisation, catheter withdrawal and adverse effects were compared. Results：There was no statistical significance of static VAS scores of PCEA group at 1 h、6 h、12 h、24、48 h and 72 h after surgery between two groups. The time of bowel flatus in PCEA-parecoxib group was (31±8.2) h, which was significantly shorter than that in PCEA group (［48±5.2］ h, P＜0.001). The time of mobilization in PCEAparecoxib group was (18±8.2) h, which was also significantly shorter than that in PCEA group (［26±5.2］ h, P＜0.001). Similarly, the time of catheter withdrawal in PCEA-parecoxib group was (26±8.2) h, which was significantly shorter than that in PCEA group (［68±5.2］ h, P＜0.001). There were 2 cases of nausea and vomiting and 1 case of hypotension in PCEA group while 1 case of nausea in PCEA-parecoxib group, and no incidence of hypotension. Conclusions：Analgesia using sequential PCEA-parecoxib combined with modified Joel-Cohen incision for laparoscopic left lateral hepatectomy is effective and equivalent to PCEA. It can facilitate a faster postoperative recovery and is worthy of wide application for laparoscopic left lateral hepatectomy.