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痛风患者肾脏结石与关节部位尿酸盐晶体沉积的相关性

  • 摘要: 目的:探讨痛风患者关节部位尿酸盐结晶沉积与肾脏结石形成的相关性。方法:回顾分析复旦大学附属中山医院门诊痛风患者(n=190)的肾脏超声检查结果及急性痛风性关节发作部位双源CT结果。采用卡方检验及Spearman相关分析明确双源CT上显示的尿酸盐结晶沉积部位、尿酸盐结晶大小与肾脏结石形成的关系。结果:肾脏超声显示无肾脏结石患者139例(73.2%),肾脏结石患者51例(26.8%)。双源CT检查部位分为双足、踝关节152例,双膝关节24例,双手、腕关节14例。其中,155例双源CT发现有尿酸盐结晶沉积,35例双源CT未见尿酸盐晶体沉积。以超声检查是否存在肾脏结石将患者分为肾脏结石组和无肾脏结石组。两组患者在尿酸盐沉积部位及体积上差异无统计学意义。结论:痛风患者肾脏结石的形成与关节尿酸盐沉积无明显相关性。

     

    Abstract: Objective:To analysis the results of dual energy computed tomography (DE-CT) and renal ultrasound in patients with gout, in order to investigate the correlation between the urate crystal depositions around the joints and renal calculus formation in patients with gouty arthritis. Methods: Results of DE-CT and renal ultrasound from gouty outpatients (n=190) in Fudan University Zhongshan Hospital were retrospectively analyzed. Chi-square test and Spearman correlation analysis were performed to define the relationships between the features of joints urate crystal depositions, depositions parts, size of the urate crystal on DE-CT and renal calculus formation on ultrasound. Results: Renal ultrasound showed 139 patients (73.2%) without renal calculus and 51 patients (26.8%) with renal calculus. DE-CT examined feet, ankle joint in 152 cases, knee-joints in 24 cases, both hands and wrist joints in 14 cases. DE-CT showed 155 patients with urate crystal depositions and 35 patients without urate crystal depositions around the joints. Gouty patients with renal calculus showed no difference in urate crystal depositons around the joints with patients without renal calculus. Renal calculus showed no significant correlation with the joints urate crystal depositions. Conclusions: No difference in joints urate crystal depositions is found between gouty patients with and without renal calculus. No significant correlation is detected between urate crystal depositions around the joints and renal calculus formation.

     

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