Abstract: Objective：To examine the clinical application effect evaluation of a novel approach of laparoscopic hepatic inflow occlusion device. Methods：A selfdesigned device of hepatic inflow occlusion was made using tracheal catheter (7.5 mm) and infusion set. From March 2015 to November 2016, 20 HCC patients with cirrhosis were enrolled and divided into two groups according to tumor size and extent of resection: occlusion group (n=10) received laparoscopic liver resection using the hepatic inflow occlusion, while nonocclusion group (n=10) without. The efficacy of the occlusion apparatus was examined using laparoscopic ultrasound device. The operation time, intraoperative blood loss, intraoperative transfusion, and the postoperative complications were compared. Results：The novel approach can effectively occluded the hepatic inflow. The average operation time were (102.0±32.5) min in occlusion group and (136.5±45.8) min in nonocclusion group (P=0.005), respectively. Mean intraoperative blood loss was (80.0 ±69.4) mL in occlusion group and (170.0±163.4) mL in nonocclusion group (P=0.011). One patient in nonocclusion group received transfusion (RBC, 2 U). No postoperative complication was occurred in two groups. Conclusions：The novel approach of hepatic inflow occlusion is effective, safe, simple and easy for laparoscopic liver resection. It can significantly reduce length of operation and intraoperative blood loss. It can facilitate laparoscopic liver resection and is worthy of wide application.