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可穿戴传感装置对帕金森病患者上肢静止性震颤的量化评估价值

  • 摘要: 目的:评估采用可穿戴传感器量化评估帕金森病(Parkinson disease,PD)患者上肢静止性震颤的可行性。方法:15例PD患者和8例健康受试者双手穿戴检测装置,完成统一帕金森病评定量表(UPDRS)中的检测静止性震颤的标准动作。对采集到的上肢静止性震颤的加速度信号进行时域和频域分析,并与UPDRS中的静止性震颤评分进行相关性分析。结果:可穿戴设备可以良好地测定上肢静止性震颤的加速度均值、均方根值、峰值振幅和峰值功率的对数值;震颤的加速度均值、均方根值、峰值振幅和峰值功率的对数值与UPDRS中静止性震颤的评分高度相关(r分别为0.960、0.961、0.893、0.944)。结论:可穿戴传感装置可准确、客观、量化地评估PD患者上肢的静止性震颤,值得临床推广。

     

    Abstract: Objective:To analyze the feasibility of wearable sensor for assessing the severity of tremor in patients with Parkinson disease (PD). Methods:Totally 15 PD subjects and 8 healthy subjects completed the standard action for detecting resting tremor in unified PD rating scale (UPDRS) with the detecting equipment on their hands. The time domain and frequency domain of acceleration signal collected during rest tremor were analyzed, and their correlations with rest tremor score in UPDRS were explored. Results:The logarithm of mean acceleration, root-mean-square roughness, peak amplitude and peak power were well assessed, which were all significantly correlated with rest tremor score in UPDRS (r=0.960,0.961,0.893,0.944). Conclusions:The wearable tremor data acquisition device is accurate, objective and digital in evaluation of resting tremor in PD patients.

     

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