Abstract: Objective：To analyze the reason which cause the different change of airway appearance after laparoscopic radical resection and transabdominal radical resection for cervical cancer. Methods：Patients with ASAⅠⅡ,twenty undergoing laparoscopic radical resection of cervical cancer and twenty with transabdominal radical resection of cervical cancer were enrolled. The parameters of Mallampati class, class of upperlipbite test, and neck circumference were measured presurgery, 1 h after and 24 h after surgery. The correlation between these three parameters and airway pressure or central venous pressure were analyzed. Results：The parameters of Mallampati class, class of upperlipbite test, and neck circumference showed no statistical significance between laparoscopic group and transabdominal group at each time. The statistical significances were found between the parameter of Mallampati class (P=0.001) and class of upperlipbite test (P=0.003) 1 h after surgery and before surgery, while no parameters significantly changed between 24 h after surgery and before surgery. The parameter of neck circumference in laparoscopic treatment group statistically changed 1 h (［34.18±2.50］ cm) and 24 h (［32.98±2.30］ cm) after surgery than before surgery (［32.48±2.58］ cm, P＜0.05). In transabdominal group, no statistical difference was found in the parameters of Mallampati class , class of upperlipbite test and neck circumference at 1 h or 24 h after surgery. In the group of laparoscopic treatment, Mallampati class 1 h after surgery was positively related to the airway pressure at 1 h and 2 h after beginning of surgery and central venous pressure at 1 h after beginning of surgery（P＜0.05）. There were also positive correlation of class of upperlipbite test 1 h after surgery and airway pressure at 1 h, 2 h and 3 h after beginning of surgery and central venous pressure at 2 h after beginning of surgery （P＜0.05）. Conclusions：Compared with the transabdominal radical resection, in laparoscopic radical resection, there are significant changes of airway at 1 h after surgery, which related to the airway pressure and central venous pressure at the beginning of surgery.