Abstract: Objective：To analyze the mortality rate and morbidity rate of lymphoma among residents in Luwan District of Shanghai from 2004 to 2011. Methods：The data of lymphoma in permanent residents of Luwan District were collected from the database of cancer registration and management system in Shanghai. The mortality rate and morbidity rate of lymphoma were calculated. The rates were standardized by the demographic composition developed in the Fifth Nationwide Census in the year 2000. The temporal trend of lymphoma mortality rate and morbidity rate was assessed. Results：A total of 319 cases of lymphoma were diagnosed from 2004 to 2011, accounted for 3.06% of the total patients with malignant diseases. Of those cases, 10 cases were Hodgkin lymphoma (HL), 245 cases were nonHodgkin lymphoma (NHL), and 64 cases were multiple myeloma (MM). The crude incidence of HL, NHL, and MM among males were 0.19/105, 5.43/105 and 1.28/105 respectively; and 0.34/105, 4.33/105 and 0.89/105 among females respectively. A total of 200 cases died of lymphoma during the 8 year period, including 2 deathed from HL, 148 deathed from NHL, and 50 deathed from MM. The crude mortality rates among males were 0.03/105, 3.50/105 and 0.93/105 respectively; and 0.01/105, 2.22/105 and 0.66/105 respectively among females. Both the mortality rate and morbidity rate of HL were very low. For NHL, both the mortality rate and morbidity rate increased significantly after 50 years of age; while for MM, the majority of cases and deaths occurred after 45 years of age. There were some fluctuations of lymphoma incidence during 20042011, but not significant. Standardized mortality showed an increasing trend from 2004 to 2011. Conclusions：Both the incidence and mortality rates of lymphoma in Luwan District of Shanghai from 2004 to 2011 were higher compared to the rates of Chinese urban areas during the same period. It is important to identify risk factors of lymphoma to take effective control measures.