Abstract: Objective：To explore the postoperative chest wall reconstruction method for patients with tumor. Methods：There were 46 patients who underwent chest wall reconstruction in our Department from March 2007 to December 2014. The mean age of the patients was 51.7. Histological diagnosis including squamouscell carcinoma (n=16), soft tissue sarcoma (n=8) and metastasis from breast cancer (n=22). Simple rib defects occurred in 15 cases, using mesh repairments only; simple soft tissue defects were noted in 14 cases, pedicle flaps were used; in 17 cases complicated composite chest wall defects involving multiple layers (soft tissue, ribs/sternum, and intrathoracic organs) methylmethacrylate/polypropylene mesh sandwich prostheses were used. The chest wall soft tissue defects were repaired with pedicled or free flap. Results：In 1 case with pedicled rectus abdominis flap partial necrosis was noted, local flap was used for repairmen after further revision. In 1 case with free deep inferior epigastric artery perforator flap, postoperative venous congestion occurred. The reexploration procedure was carried out and the flap survived totally. The mean followup was (29.4±0.7) months, with a range from 12 to 68 months. No tumor extirpation was noted, functional and appearance results were satisfying. Conclusions：Various pedicled and free flaps are efficient for large complex chest defects reconstruction.