Abstract: Objective：To assess the usage of β-blocker in patients with acute myocardial infarction (AMI) in early hospitalization period (admission within 24 hours) in Liaoning Province from 2001 to 2011. Methods：By convenience sampling, patients from 10 hospitals in 3 study years (2001, 2006, and 2011) were randomly selected and clinical data were extracted, the usage frequency, types and dosage of β-blocker were analyzed. Results：A total of 1 365 AMI patients from ten hospitals were included in this analysis, and about 296 cases (21.68%) were considered as ideal patients for early β-blocker use (53.10% cases in 2001, 68.70% cases in 2006, and 78% cases in 2011, P＜0.001). Logistic regression analysis showed that the heart rate was related to the early usage of β-blocker. The most frequently used β-blocker was metoprolol (90.73%) within 3 years, only 1.46% had the dosage above 50 mg. Conclusions：During the past decade, the utilization rate of βB among the appropriate patients with AMI during the earlyphase hospitalization in Liaoning Province present the increasing trend. However, there is a distinct gap between the utilization status and guideline. Although the early application can reduce the occurrence of cardiovascular event, the heart rate of patients and so on are the main causes that influence its application. Therefore, regarding the early application, it is necessary to comply with the evidencebased medical science and combine it with the individualization principle.