Abstract: Objective：To study the role of modified oxygen nebulizer of tracheotomy mask in tracheotomy patients without ventilator support. Methods：From January 2013 to June 2015, 56 tracheotomy patients from emergency intensive care unit (EICU), without ventilator support, were randomly divided into control group and observation group, with 28 cases in each group. In control group, the tracheotomy was covered with sterile gauze and traditional intermittent airway humidification was applied. In observation group, modified oxygen nebulizer was used. The wet effect and complications were compared between the two groups. Results：There was no significant difference in heart rate and respiratory rate between the two groups. The oxyhemoglobin saturation in observation group was higher than which in control group (P＜0.05), and higher than the oxyhemoglobin saturation before humidification (［95.5±1.6］%, P＜0.05). The statistical significances of wet effect and complications were found between two groups (P＜0.05). Conclusions：The modifying oxygen of nebulizer of tracheotomy mask, without electric power, driven by oxygen can effectively humidify the airway in the tracheotomy patients without ventilator support.