Abstract: Objective：To explore the safety and efficacy of endoscopic mucosal resection（EMR）and high frequency electric coagulation electric cut method for treating nonpedunculated colorectal polyps. Methods：During January 2013 and July 2015, the clinical data of 108 patients with 131 nonpedunculated colorectal polyps which the diameter between 12 cm were treated by EMR or high frequency electric coagulation electric cut method, operative time, hospital stays and complications were recorded for retrospective analysis. Results：EMR and high frequency electric coagulation electric cut method were successfully performed in all 108 cases. Patients in the EMR group needed longer operative time (［9.19±1.32］ min) compared with the snare group (［7.71±1.33］ min). The average hospital stay time (［3.51±2.04］ d) of patients in the EMR group was shorter compared with that in the snare group (［4.63±1.81］ d). EMR group total postoperative complications (5.26%) was lower than the snare group (21.6%, P<0.05). All polyps were excised, no original residual lesions and recurrence in situ were found during follow up. Conclusions：Both EMR and high frequency electric coagulation electric cut method can be used for nonpedunculated colorectal polyps, but EMR is safer and can achieve faster postoperative recovery.