Abstract: Objective：To explore the clinical features and key points in treatment and diagnosis of venous thromboembolism (VTE) combined cirrhosis. Methods：Clinical data of 23 patients with venous thromboembolism combined cirrhosis were analyzed retrospectively. Results：The incidence rate of VTE combined cirrhosis was 0.8%. Sixteen males and seven females were enrolled in this study, aged from 43 to 84 years old with an average age of (55.7±10.1) years old. The levels of blood albumin and hemoglobin of A level liver cirrhosis patients (n=9) were obviously higher than B level and C level liver cirrhosis patients (n=14, P<0.05). The blood coagulation and serum creatinine in A level patients were better than B level and C level patients, and the D dimer and blood platelet was slightly lower than B level and C level patients, but no statistical significance was found between two groups. There were 73.9% patients had malignant tumor history. Eighteen patients received low molecular weight heparin for treatment. Five patients did not receive any anticoagulation therapy, and three of them died during hospitalization. Conclusions：The physicians should pay attention to the risk of the cirrhotic patients with VTE developing, and its need for early diagnosis and timely treatment.