Abstract: Objective：To evaluate the volume change of prostate in patients underwent transurethral plasmakinetic enucleation of prostate, and to explore its clinical significance. Methods：A total of 120 patients with prostate hyperplasia who underwent surgical treatment from January 2010 to December 2013 in Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University were enrolled in this study. The clinical data of these patients were retrospectively analyzed. Based on the method of surgery, all patients were divided into two groups: plasmakinetic transurethral enucleation of prostate (PKEP) group and suprapublic prostatectomy (SPP) group. Prostate volume, maximum urinary flow rate (Qmax), residual urine (RU), and international prostate symptom score (IPSS) in the two groups were evaluated and compared. Results：Postoperative CT manifestations of prostate in the two groups were similar, showing the surgery reached prostate surgical coated layers. Before surgery, the prostatic volume in SPP group was significantly larger than that in PKEP group (P<0.05). After surgery, the prostate volume was significantly reduced in the two groups as compared with that before surgery (P<0.05), but there was no significant difference between the two groups. In PKEP and SPP groups, the residual gland volume accounted for about 26% of the preoperative volume, and the residual part was mainly the surgical capsule. In 1 month after surgery, the Qmax, RU, IPSS and other indicators of efficacy in the two groups were significantly better than those before surgery (P<0.05), but there was no significant difference between the two groups. Conclusions：Plasmakinetic transurethral enucleation of prostate by a surgical capsule is effective and safe in the treatment of patients with prostate hyperplasia associated lower urinary tract obstruction.