干扰素调节因子在肿瘤发生中的研究进展

Progress of the interferon regulatory factors in the development of tumor

摘要: 干扰素调节因子（interferon regulatory factors, IRFs）是一类在干扰素表达调控中起重要作用的转录因子家族，目前共发现有10个成员，其在免疫调节、细胞分化、细胞凋亡和细胞周期调节中具有重要作用。本文就该家族成员的功能特点、免疫活性，特别是在细胞分化及肿瘤发生中的作用作一综述。

Abstract: Interferon regulatory factors (IRFs), which have 10 members, belong to the transcription factor family, and are named because of the regulation of interferon expression. They play important roles in the immune regulation, cell differentiation, cell apoptosis, and cell cycle regulation. This article will review the functional characteristics and immune activity of the family members, especially in the role of cell differentiation and tumor development.