Abstract: Objective：To analyze the correlation between inflammatory factors and sleepiness A total of scores in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods：Fourty patients with obstructive sleep apnea hypopnea syndrome treated in the No. 463 Hospital of PLA were selected as the OSAHS group. 40 healthy subjects were selected as the healthy group. Sleepiness scores were obtained by using the Epworth Sleepiness Scale (ESS) in the form of questions and answers. The morning fasting blood samples were taken, changes in the levels of serum tumor necrosis factoralpha(TNF-α), serum malondialdehyde (MDA), serum glutathione (GSH) and serum superoxide dismutase (SOD) and their correlation with sleepiness were analyzed. Results：The ESS score, serum TNF-α and serum MDA of the OSAHS group were higher than those of the healthy group (P<0.05). Serum GSH and serum SOD of the OSAHS group were lower than those of the healthy group (P<0.05). The ESS scores of both groups were correlated with serum TNF-α(r=0.815), MDA (r=0.528), GSH (r=-0.433) and SOD (r=-0.607,P<0.01). Conclusions：The serum TNF-α, MDA, GSH, and SOD levels of OSAHS patients change, and they were related to sleepiness.