Abstract: Objective：To evaluate the effect of parecoxib sodium on the incidence and severity of postoperative hoarseness and sore throat in general anaesthesia patients. Methods：One hundred and twenty patients, with ASA physical status Ⅰ or Ⅱ, aged 20-60 yr, weighing 45-80 kg, undergoing general anesthesia were randomly allocated to parecoxib sodium group or normal saline group equally. In parecoxib sodium group, parecoxib sodium 40 mg was infused during induction of anesthesia, while the equal volume of 0.9% normal saline was given instead in normal saline group. Anesthesia was intravenously induced with midazolam (0.05 mg/kg), sufentanyl (0.2-0.3 μg/kg), rocuronium (0.7 mg/kg) and propofol (2.0 mg/kg) and mechanical ventilation was applied after tracheal intubation in both groups. The incidence and severity of postoperative hoarseness and sore throat were evaluated 1, 2, 6, and 8 h after surgery. Results：Compared with normal saline group, the incidence and severity of postoperative hoarseness were significantly reduced by parecoxib sodium at 1, 2, and 6 h time points in parecoxib sodium group (P<0.05), except for time point of 8 h. The incidence and severity of postoperative sore throat was significantly reduced at 1, 2, 6, and 8 h time points in parecoxib sodium group, compared with normal saline group (P<0.05). Conclusions：Parecoxib sodium provides efficacy in reducing the incidence and severity of postoperative hoarseness and sore throat in short term after surgery.