Abstract: Objective：To explore the effectiveness of the anterolateral approach for internal fixation of HolsteinLewis fractures with double plates. Methods：From January 2003 to March 2014, 45 patients with HolsteinLewis fractures were admitted in the hospital. There were 32 males and 13 females with a mean age of 36.8 years(range,2152 years).They were all associated with radial nerve injury. After the radial nerve exploration and the reduction of the fractures, two straight 3.5mm dynamic compression plates were placed on the anterior and lateral aspects of the humerus. The radial nerve was repaired or loosed according to the damage degree. The postoperative complications, the bone healing time, and the recovery time of the radial nerve functions were recorded. The functions of the affected shoulder and elbow were assessed with UCLA and Mayo elbow performance score system respectively. Results：All incision healed by first intention. The patients were followed up months with an average of 15.3 months. The union of fractures was achieved in 36 months (3.9 months on average). The function of the radial nerves recovered completely in 36 months (4.8 months on average) in 41 patients with the incomplete rupture or extrusion of the radial nerves. Four patients with the complete rupture of the radial nerves achieved the recovery of the function in 2 years. The abductions of the affected shoulder were 155°-165° (160°on average). The ROM of the elbows were 125°135° （128.5°on average）. All the patients had the excellent results according to the UCLA shoulder score system. Three patients achieved the good result and 42 patients achieved the excellent result according to the Mayo elbow performance score system. Conclusions：With the advantages of rigid fixation, less muscle injury and easier radial nerve exploration, anterolateral approach of double plates osteosynthesis is a safe and reliable method for HolsteinLewis fractures treatments.