Abstract: Nasopharyngeal carcinoma is one of the most common head and neck cancers in southern China. Because most of the pathological types are poorly differentiated squamous cell carcinoma, intensitymodulated radiation therapy combined with chemotherapy has achieved good curative effects. At the same time, radiotherapy and chemotherapy can cause severe acute and delayed toxic reactions to the body, and serious adverse reactions will cause physical and psychological trauma to patients, and also lead to treatment interruption or even failure. It is of great significance to improve the compliance and prognosis of patients by paying attention to adverse reactions and timely intervention. This article reviews the adverse reactions and influencing factors of nasopharyngeal carcinoma during radiotherapy and chemotherapy.