Abstract: Objective: Retrospective analysis of clinical technique and specialty of treatments for vascular restenosis after stent implantation in atherosclerosis lesions. This article aims to have a discussion about the effectiveness and safety of the two therapy strategies in our single unit.Methods: The clinical data of 45 cases who had received drug-perfused balloon and 15 cases who had received femoral artery retrograde endarterectomy after presenting reocclusion or restenosis atherosclerosis lesions from June 2012 to June 2016 in our Vascular Surgery were reviewed retrospectively. We collected the data of restenosis or reocclusion cases following initial endovascular treatment and restenosis or reocclusion cases after our treatment in atherosclerosis in lower limb and evaluated the effectiveness, availability and safety of the two treatment strategies which are mentioned above by doing follow-up in these 60 patients.Results: 60 patients, altogether having 84 diseased limbs, had acquired an adequate blood perfusion in their distal limbs and got warmer on their feet after undergoing drug-perfused balloon and stent implantation or femoral artery retrograde endarterectomy. In addition, they can have good palpitation in dorsal artery of feet and have better feelings on account of relieving pain. In their follow-up, 2 restenosis cases have been found in the drug-perfused balloon group while no restenosisor reocclusion cases have occurred in retrograde endarterectomy group.Conclusion: The application of the stent angioplasty after using drug-perfused balloon and femoral artery retrograde endarterectomy on vascular restenosis after stent implantation in atherosclerosis lesions proved to be effective and safe, greatly reducing the restenosis or reocclusion frequency in patients who were treated in our unit.