Abstract: Objective: To explore the effect of dexmedetomidine through different administration routes on emergence agitation after sevoflurane anesthesia in children. Methods: A total of 90 children aged from 2 years to 7 years, who received scheduled cleft palate repair in Children’s Hospital of Kunming during Jan. 2014 and Nov. 2014 and were classified asⅠby American Society of Anesthesiologists (ASA) criteria, were selected and divided into 3 groups according to random number table with 30 in each group.Single loading dose of dexmedetomidine 1 μg/kg(10 min) was intravenously injected in group D₁. And dexmedetomidine 1 μg/(kg·h) was intravenously pumped in group D₂ till the operation was finished. In group C, 0.9% normal saline was intravenously pumped with the same volume as that of dexmedetomidine in group D₂. The sedation-agitation scale scores as well as the incidence rates of agitation were compared among the three groups. Results: Compared with that in group C,the sedation-agitation scale scores and incidence rates of agitation in group D₁ and group D₂ decreased (P＜0.05).And there was no statistical difference regarding the sedation-agitation scale score and incidence rate of agitation between group D₁ and group D₂ . Conclusions: By both intravenous infusion with single loading dose and continuous intravenous pumping, dexmedetomidine can effectively reduce the incidence of emergence agitation after sevoflurane anesthesia in children. And both have a similar effect.